Puas gelatin capsules yaj hauv qhov ncauj?
Gelatin capsules yog siv dav hauv kev lag luam tshuaj thiab kev noj haus ntxiv kom kaw cov tshuaj los yog khoom noj khoom haus. Cov tshuaj ntsiav no paub txog lawv txoj kev yooj yim ntawm kev siv thiab kev tawg sai, ua rau lawv nyiam kev noj qhov ncauj. Tab sis puas gelatin capsules yaj hauv lub qhov ncauj? Nyob rau hauv tsab xov xwm no, peb yuav tshawb txog cov muaj pes tsawg leeg ntawm gelatin capsules, lawv cov khoom tawg, thiab cov yam ntxwv uas tuaj yeem cuam tshuam rau lawv txoj kev tawg.
Nkag siab Gelatin Capsules
Gelatin capsules, tseem hu ua gel caps lossis gelatin plhaub, yog tsim los ntawm kev sib xyaw ntawm gelatin, dej, thiab cov yas yas. Gelatin, muab tau los ntawm tsiaj los ntawm cov khoom xws li cov pob txha thiab cov ntaub so ntswg, feem ntau yog tsim los ntawm collagen. Collagen yog cov protein uas muab cov qauv kev txhawb nqa thiab elasticity rau ntau yam ntaub so ntswg hauv lub cev.
Cov gelatin siv hauv kev tsim tshuaj ntsiav tau dhau los ua cov txheej txheem hu ua hydrolysis, qhov uas nws tau tawg mus rau hauv cov khoom me me, ua rau nws yooj yim rau yaj. Cov plasticizers ntxiv rau cov gelatin sib tov txhim kho lub zuag qhia tag nrho yooj thiab durability ntawm cov tshuaj ntsiav. Cov tshuaj ntxiv no tuaj yeem suav nrog glycerin, sorbitol, lossis polyethylene glycol.
Gelatin capsules tuaj nyob rau hauv ntau qhov ntau thiab tsawg thiab xim, tso cai rau kev txheeb xyuas tau yooj yim ntawm cov khoom ntim. Lawv muaj nyob rau hauv ob hom loj: tawv gelatin capsules (HGC) thiab mos gelatin capsules (SGC). HGCs yog cov tshuaj ntsiav uas ntim cov hmoov los yog granulated, thaum SGCs muaj cov kua lossis cov khoom semi-solid.
Txoj Kev Txiav Txim Siab
Thaum noj gelatin capsule ntawm qhov ncauj, nws nkag mus sai sai hauv plab hnyuv. Cov txheej txheem tawg ntawm gelatin capsule suav nrog peb theem tseem ceeb: hydration, disintegration, thiab dissolution.
*Hydration*: Sai li lub gelatin capsule nkag mus rau hauv lub qhov ncauj, nws raug rau qaub ncaug. Cov ntsiab lus dej hauv cov qaub ncaug pab hydrate lub capsule, ua rau nws yooj yim rau kev tawg.
* Disintegration *: Thaum hydrated, gelatin capsule pib tawg. Nws pib tawg mus rau hauv me me fragments, ua rau kev tso tawm ntawm cov khoom nyob rau hauv.
* Dissolution *: Lub disintegrated gelatin fragments ntxiv yaj nyob rau hauv lub plab los yog txoj hnyuv, tso cai rau lub nqus ntawm cov khoom los ntawm lub cev.
Lub sijhawm tawg ntawm gelatin capsules yuav txawv nyob ntawm ntau yam, suav nrog cov tshuaj ntsiav loj, lub plhaub tuab, thiab cov ntsiab lus. Cov tshuaj me me nrog cov plhaub nyias nyias yuav yaj sai dua li cov loj dua. Tsis tas li ntawd, tus nqi ntawm kev sib cais tuaj yeem cuam tshuam los ntawm qib pH ntawm ib puag ncig ib puag ncig.
Tej yam uas cuam tshuam rau kev tawg
Ob peb yam tuaj yeem cuam tshuam rau kev tawg ntawm gelatin capsules hauv lub qhov ncauj. Cov no suav nrog:
1. Cov qaub ncaug ntau lawm: Tus nqi thiab qhov sib xws ntawm cov qaub ncaug hauv lub qhov ncauj tuaj yeem cuam tshuam rau hydration thiab disintegration ntawm gelatin capsules. Cov neeg uas muaj qhov ncauj qhuav tuaj yeem ua rau qeeb qeeb.
2. Kub: kub siab tuaj yeem ua kom cov txheej txheem tawg, thaum qhov txias dua tuaj yeem ua kom qeeb. Qhov no yog vim li cas gelatin capsules yuav tsum tau muab cia rau hauv qhov chaw txias, qhuav.
3. pH qib: Gelatin capsules feem ntau yaj sai dua nyob rau hauv ib puag ncig nrog pH siab dua. Txawm li cas los xij, qib pH tuaj yeem sib txawv hauv thaj chaw sib txawv ntawm lub plab zom mov, cuam tshuam rau tag nrho kev sib xyaw ceev.
4. Plhaub thickness: thinner gelatin plhaub yaj sai dua li cov thicker. Cov neeg tsim khoom tuaj yeem kho lub plhaub tuab raws li qhov xav tau ntawm kev sib cais.
5. Capsule cov ntsiab lus: Qhov xwm thiab cov khoom ntawm cov tshuaj uas nyob rau hauv lub gelatin capsules tuaj yeem cuam tshuam rau lawv cov kev sib cais. Qee cov tshuaj yuav xav tau sijhawm ntxiv kom yaj tag.
6. Txheej los yog enteric tsim: Qee zaum, gelatin capsules tej zaum yuav coated los yog formulated nrog enteric cov ntaub ntawv los tswj lawv cov dissolution profile. Cov kev hloov kho no tso cai rau lub hom phiaj tso tawm cov khoom nyob hauv ib cheeb tsam ntawm lub plab zom mov.
Xaus
Hauv kev xaus, gelatin capsules ua yaj hauv lub qhov ncauj. Lub hydration, disintegration, thiab tom qab dissolution ntawm gelatin capsules tso cai rau tso tawm thiab nqus ntawm cov khoom nyob rau hauv lub kaw lus. Cov yam ntxwv xws li qaub ncaug ntau lawm, kub, pH qib, lub plhaub tuab, cov ntsiab lus ntawm cov tshuaj ntsiav, thiab cov kev hloov kho tuaj yeem cuam tshuam tus nqi ntawm kev sib cais. Cov tshuaj ntsiav no tau dhau los ua ib txoj hauv kev yooj yim thiab nrov ntawm kev xa cov tshuaj thiab cov khoom noj khoom haus hauv qhov ncauj, ua kom muaj txiaj ntsig zoo thiab yooj yim ntawm kev tswj hwm.
